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Testosterone steroids are the most commonly used and most important anabolic androgenic steroids of all and also the primary male sex hormone. They have been prescribed for the treatment of male gender dysphoria since the late 1700s. Some experts (including Sigmund Freud) believed that the psychological and physiological effects of testosterone produced a 'masculinization' of the male body; and also that these effects could be treated or reversed by replacement therapy. They had been used in the treatment of prostate cancer since the mid-19th century but research to determine the relative efficacy and dose of testosterone therapy was restricted until recently. In 2010, the US Food and Drug Administration approved the use of testosterone, its active metabolite and a progestin, norethisterone, for the treatment of male gender dysphoria. Research has shown that replacement therapy with testosterone therapy may help alleviate some of the symptoms seen with early diagnosis and early treatment for this condition. Replacement treatment does not eliminate or reduce the body's natural testosterone to oestrogen ratio so long as adequate levels of these hormones are present. The main long-term concern in transgender persons is whether testosterone treatment will increase the likelihood of long-term prostate cancer. There are many studies performed to determine the long-term benefit of the hormone therapy and the potential side effects. A number of studies found that testosterone therapy significantly increased bone mineral density for the vast majority of subjects, but this change was not linear or steady over time. Further, many women's breast volumes and ratios fluctuated in response to therapy at the time of administration and were not related to treatment effectiveness, other than increasing after discontinuation. The treatment also caused other changes to the body when given during puberty, such as the increased incidence of breast and fat cell growth. As a result, the use of testosterone is usually limited to adolescents and young adults who still have the physical development necessary to support growth and maturation to menopause, typically by the time of puberty. In fact, the use of testosterone in high doses for an extended period of time (up to 3 years) is likely to increase risks of breast cancer, in particular for a person who already is at high risk for these cancers. Testosterone therapy was associated with the development of bone loss in the face. Most of this loss was linear with increasing doses of testosterone therapy. These increases occurred in men who were already taking doses at the low end of the normal range and not with the increased dosage seen for women at this time in their menstrual cycle. Women who have undergone testosterone therapy reported a range of adverse effects. Bone fracture was reported among some individuals but was not Related Article:

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